Time-Resolved and Laue Publications
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Please include the following paragraph in all publications based on data obtained at BioCARS:
Use of the Advanced Photon Source was supported by the U.S. Department of Energy, Basic Energy Sciences, Office of Science, under Contract No. DE-AC02-06CH11357. Use of the BioCARS Sector 14 was supported by the National Institutes of Health, National Center for Research Resources, under grant number RR007707.
For time-resolved publications, please also include the following:
Time-resolved set-up at Sector 14 was funded in part through a collaboration with Philip Anfinrud (NIH/NIDDK).

Schmidt, M.
Structure-based kinetics by time-resolved X-ray crystallography
In Ultrashort Laser Pulses in Biology and Medicine (Markus Braun, Peter Gilch and Wolfgang Zinth, eds.), Springer Berlin Heidelberg, pp. 201-241 (2008)

Srajer, Vukica, and William E. Royer Jr.
Time-Resolved X-ray Crystallography of Heme Proteins
Methods Enzymol. 437: 379-395 (2008)

Key J, Srajer V, Pahl R and Moffat K.
Time-Resolved Crystallographic Studies of the Heme Domain of the Oxygen Sensor FixL: Structural Dynamics of Ligand Rebinding and Their Relation to Signal Transduction
Biochemistry 46 (16): 4706-4715 (2007)

Pearson AR, Pahl R, Kovaleva EG, Davidson VL and Wilmot CM.
Tracking X-ray-derived redox changes in crystals of a methylamine dehydrogenase/amicyanin complex using single-crystal UV/Vis microspectrophotometry.
Journal of Synchrotron Radiation 14 (1): 92-98 (2007)

Knapp, James E., Reinhard Pahl, Vukica Srajer, William E. Royer
Allosteric action in real time: Time-resolved crystallographic studies of a cooperative dimeric hemoglobin.
PNAS 103 (20) 7649-7654 (2006)

Ihee H, Rajagopal S, Srajer V, Pahl R, Anderson S, Schmidt M, Schotte F, Anfinrud PA, Wulff M, Moffat K.
Visualizing reaction pathways in photoactive yellow protein from nanoseconds to seconds.
PNAS 102: 7145-7150 (2005)

Marius Schmidt, Karin Nienhaus, Reinhard Pahl, Angela Krasselt, Spencer Anderson, Fritz Parak, G. Ulrich Nienhaus, Vukica Srajer
Ligand migration pathway and protein dynamics in myoglobin: A time-resolved crystallographic study on L29W MbCO
PNAS 102 (33) 11704-11709 (2005)

M. Schmidt, H. Ihee, R. Pahl and V. rajer
Protein-ligand interactions probed by time-resolved crystallography.
In Protein-Ligand Interactions: Methods and Applications (G. U. Nienhaus, ed.), Methods in Molecular Biology, vol. 305,
Humana Press, Totawa, NJ, pp. 115-154 (2005)

Sudarshan Rajagopal, Spencer Anderson, Vukica Srajer, Marius Schmidt, Reinhard Pahl, Keith Moffat
A Structural Pathway for Signaling in the E46Q Mutant of Photoactive Yellow Protein.
Structure 13 (1) 55-63 (2005)

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S. Anderson, V. Srajer, R. Pahl, S. Rajagopal, F. Schotte, P. Anfinrud, M. Wulff, K. Moffat
Chromophore Conformation and the Evolution of Tertiary Structural Changes in Photoactive Yellow Protein.
Structure 12 (6) 1039-1045 (2004)

Baxter, R. H. G., Ponomarenko, N., Srajer, V., Pahl, R., Moffat, K. and Norris, J. R.
Time-resolved crystallographic studies of light-induced structural changes in the photosynthetic reaction center.
PNAS 101 (16) 5982-5987 (2004)

James E. Knapp, Vukica Srajer, Reinhard Pahl, William E. Royer, Jr
Immobilization of Scapharca HbI crystals improves data quality in time-resolved crystallographic experiments.
Micron 35 107-108 (2004)

S. Rajagopal, K. Kostov, K. Moffat
Analytical trapping: Extraction of time-independent structures from time-dependent crystallographic data.
J. Struct. Biol. 147 (3) 211-222 (2004)

Rajagopal, S., Schmidt, M., Anderson, S., Ihee, H. and Moffat, K.
Analysis of experimental time-resolved crystallographic data by singular value decomposition.
Acta Cryst. D60 (5) 860-871 (2004)

Schmidt, M., Pahl, R., Srajer, V., Anderson, S., Ren, Z., Ihee, H., Rajagopal, S. and Moffat, K.
Protein kinetics: Structures of intermediates and reaction mechanism from time-resolved x-ray data.
PNAS 101 (14) 4799-4804 (2004)

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Moffat K.
The frontiers of time-resolved macromolecular crystallography: movies and chirped X-ray pulses.
Faraday Discuss. 122: 65-77 (2003)

Schmidt, M., Rajagopal, S., Ren, Z., and Moffat, K.
Application of singular value decomposition to the analysis of time-resolved macromolecular x-ray data.
Biophysical Journal 84: 2112-29 (2003)

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Moffat, K.
Time-resolved Biochemical Crystallography: A Mechanistic Perspective.
Chem. Revs. 101: 1569-1581 (2001)

Ren Z., Perman B., Srajer V., Teng T-.Y., Pradervand C., Bourgeois D., Schotte F., Ursby T., Kort R., Wulff M., and Moffat K.
A Molecular Movie at 1.8 Ã… Resolution Displays the Photocycle of Photoactive Yellow Protein, a Eubacterial Blue-Light Receptor, from Nanoseconds to Seconds.
Biochemistry 40: 13788-13801 (2001)
Molecular movie

Srajer V., Ren Z., Teng T-.Y., Schmidt M., Ursby T., Bourgeois D., Pradervand C., Schildkamp W., Wulff M., and Moffat K.
Protein Conformational Relaxation and Ligand Migration in Myoglobin: A Nanosecond to Millisecond Molecular Movie from Time-Resolved Laue X-ray Diffraction.
Biochemistry 40: 13802-13815 (2001)
Molecular movie

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Moffat K.
Laue Crystallography: Time Resolved Studies.
In "International Tables for X-Ray Crystallography, Volume F: Macromolecular Crystallography", Ed. E Arnold and M.G. Rossman (2000)
More Information

Moffat K., Chengeux J-.P., Crothers D.M., Grubmuller H., Nienhaus G.U., Palma M.U., Parak F.G., Schulten K., and Warshel A.
How Does Complexity Lead to an Apparently Simple Function?
In "Dahlem Workshop on Simplicity and Complexity in Proteins and Nucleic Acids". Ed. H. Frauenfelder, J. Deisenhofer and P.G. Wolynes (2000)

Moffat, K.
Nanosecond Time-resolved X-ray Crystallography.
Trans. Amer. Cryst. Assoc. 34: 39-42 (2000)

Schotte F., Techert S., Anfinrud P. Srajer V., Moffat K., and Wulff, M.
Recent Advances in the Generation of Pulsed Synchrotron Radiation Suitable for Picosecond Time-resolved X-ray Studies.
In "Handbook on synchrotron radiation, Volume IV. Ed. D. Mills (2000)

Srajer V., Crosson S., Schmidt M., Key J., Schotte F., Anderson S., Perman B., Ren, Z., Teng T-.Y., Bourgeois D., Wulff M., and Moffat K.
Extraction of Accurate Structure Factor Amplitudes from Laue Data: Wavelength Normalization with Wiggler and Undulator X-Ray Sources.
Journal of Synchrotron Radiation 7: 236-244 (2000)

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Ren Z., Bourgeois D., Helliwell J.R., Moffat K., Srajer V., and Stoddard B.L.
Laue Crystallography: Coming of Age.
Journal of Synchrotron Radiation 6: 891-917 (1999)

Moffat K.
Time-resolved Crystallography.
Acta Cryst. A 54:833-41 (1998)

Moffat K.
Ultrafast Time-resolved Crystallography.
Nature Structural Biology 5 Suppl:641-3 (1998)

Perman B., Srajer V., Ren Z., Teng T-.Y., Pradervand C., Ursby T., Bourgeois D., Schotte F., Wulff M., Kort R., Hellingwerf K., and Moffat K.
Energy Transduction on the Nanosecond Time Scale: Early Structural Events in a Xanthopsin Photocycle.
Science 279:1946-50 (1998)

Yang X., Ren Z., and Moffat K.
Structure Refinement Against Synchrotron Laue Data: Strategies for Data Collection and Reduction.
Acta Cryst. D 54:367-77 (1998)

Genick U.K., Borgstahl G.E., Ng K., Ren Z., Pradervand C., Burke P.M., Srajer V., Teng T-.Y., Schildkamp W., McRee D.E., Moffat K., and Getzoff E.D.
Structure of a protein photocycle intermediate by millisecond time-resolved crystallography.
Science 275:1471-5 (1997)

Moffat K., and Ren Z.
Synchrotron Radiation Applications to Macromolecular Crystallography.
Current Opinion in Structural Biology 7:689-96 (1997)

Moffat K.
Laue Diffraction.
Methods in Enzymology 277:433-47 (1997)

Wulff M., Schotte F., Naylor G., Bourgeois D., Moffat K., and Mourou G.
Time-Resolved Structures of Macromolecules at the ESRF: Single-Pulse Laue Diffraction, Stroboscopic Data Collection and Femtosecond Flash Photolysis.
Nucl. Instrum. and Meth. A398: 69-84 (1997)

Bourgeois D., Ursby T., Wulff M., Pradervand C., LeGrand A., Schildkamp W., Laboure S., Srajer V., Teng T-.Y., Roth M., and Moffat K.
Feasibility and Realization of Single-Pulse Laue Diffraction on Macromolecular Crystals at ESRF.
J. Synchrotron Rad. 3:65-74 (1996)

Moffat K.
Time-Resolved Macromolecular Crystallography.
Synch. Rad. News 9:15-18 (1996)

Ren Z., Ng K., Borgstahl G.E.O., Getzoff E.D., and Moffat K.
Quantitative Analysis of Time-Resolved Laue Diffraction Patterns.
J. Appl. Cryst. 29:246-260 (1996)

Srajer V., Teng T-.Y., Ursby T., Pradervand C., Ren Z., Adachi S., Schildkamp W., Bourgeois D., Wulff M., and Moffat K.
Photolysis of the Carbon Monoxide Complex of Myoglobin: Nanosecond Time-resolved Crystallography.
Science 274:1726-9 (1996).

Bourgeois D, Ursby T, Wulff M, Pradervand C, Srajer V, LeGrand S, Schildkamp W, Laboure S, Rubin C, Teng TY, Roth M, Moffat K.
Single Pulse Laue Images from Macromolecular Crystals
recorded at ESRF. In "Time-Resolved Electron and X-Ray Diffraction" (Ed. P.M. Rentzepis) Proc. SPIE 2521:178-181 (1995)

Ren Z., and Moffat K.
Deconvolution of Energy Overlaps in Laue Diffraction.
J. Appl. Cryst. 28:482-493 (1995)

Ren Z., and Moffat K.
Quantitative Analysis of Synchrotron Laue Diffraction Patterns in Macromolecular Crystallography.
J. Appl. Cryst. 28:461-481 (1995)

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