University of Massachusetts Dartmouth
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North Dartmouth, MA 02747-2300
Phone: 508 999-8000 • TTY/TDD: 508 999-9250
Research Groups
Dr. Guo
Dr. Singh
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Dr. Guo
Research interests in my group cover biochemistry and molecular biology, protein engineering, structural biology, bioinorganic chemistry, nutritional biochemistry and analytical biochemistry.
Our research is in the interface between chemistry, biology and medicine. This exciting field is the foundation of modern biomedical sciences which provide molecular basis for various biomedical processes. We are using multi-disciplinary approach including molecular biology, protein chemistry, synthetic and electro-chemistry, spectroscopy (NMR, UV-vis, CD, fluorescent, etc), chromatography and X-ray crystallography to investigate the molecular basis of certain genes, proteins, metal ions, natural products and signal transduction pathways related to cancer, aging, infectious, cardiovascular diseases and neurodegenerative disorders. Our research goal is to understand the molecular basis of these biochemical processes and to develop novel strategies for diagnostics and therapeutics. Current research activities are focusing on the biology and chemistry related to iron and hydrogen peroxide homeostasis, as detailed (link to my research web page: http://www.umassd.edu/cas/chemistry/guo/guoresearch.cfm ) in the following topics:
1) Antioxidant enzymes controlling hydrogen peroxide signaling and novel drug design
2) The role of iron homeostasis in the biochemical mechanisms of action of cranberry's health benefits
3) Iron acquisition pathways in pathogenic bacteria
4) Transferrin as a drug carrier to cancer cells
Dr. Singh
This research group is working in collaboration with SMAST, (School for Marine Science and Technology, New Bedford), UMass Cranberry Station (Wareham) and the UMass Dartmouth main campus. The SMAST laboratory is involved in the Bioremediation and Cranberry research projects while the UMass main campus laboratory is involved in the Botulinum Neurotoxin Research. All laboratories are well equipped with state-of-the-art research instruments. The research environment is challenging and competitive. This research is funded by Federal, State and private funding agencies. more...
Last Updated On: 2/20/07
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