The Macromolecular Crystallography (MX) group operates a world leading suite of synchrotron radiation beamlines dedicated to the study of biological macromolecules. The facility is comprised of three highly intense, tunable beamlines ID14-4, ID23-1 and ID29; two fixed wavelength beamlines ID14-1 and ID14-2; the world's first microfocus beamline dedicated to protein crystallography, ID23-2, and a protein solution scattering beamline ID14-3.
Research Highlight
The structure of Olgopeptide binding protein A from Lactococcus lactis (ribbon) bound to a peptide substrate (spheres). See Berntsson, R. P. et al. EMBO J (2009), doi:10.1038/emboj.2009.65
The structural basis of peptide selection by the transport receptor OppA
Oligopeptide binding protein A (OppA) from Lactococcus lactis binds to a large range of peptides (of lengths varying from 4 to 35 residues), using no clear sequence dependence. It achieves this by using a large cavity that allows the binding of large peptides without any constraints on the N or C termini of the ligand. A set of crystal structures has been reported in both the open and closed-liganded conformations. These structures demonstrate that the composition of the peptide, and not its actual sequence, is important for binding. OppA seems to prefer proline rich peptides containing at least one isolucine. This also correlates with the observed tendency of the organism to prefer proline rich proteins, such as caseins, as a source of amino acids. Data for these structures were collected on the ESRF beamlines ID14-2 and ID29.
Scientific OutputResearch performed at the ESRF produces over 20% of the protein structures submitted in the world and accounts for over 50% of those that come from Europe. To see a list of structures solved at the ESRF see the BIOSYNC website. In order to maintain the predominance of the ESRF in world science, a substantial upgrade programme is in progress; for more information about the upgrade please click here.
Associated FacilitiesA number of laboratories and facilities are available to the community. Of particular interest is The Partnership for Structural Biology (PSB) which is a collaboration between ESRF, EMBL, ILL and IBS to bring together a set of complementary technologies for structural biology.
The Partnership for Structural Biology
Cryo-Bench Laboratory
Collaborating Research Groups and BeamlinesID13
BM14
BM16
BM26
BM30A
BM30B
MX Quick links Before you arrive
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Send feedback Data collections 2009 Sat 09 May, 09:55
id14eh1 Sample Evaluations: 5356,
Data Sets: 793
id14eh2 Sample Evaluations: 4048,
Data Sets: 446
id14eh4 Sample Evaluations: 6981,
Data Sets: 1495
id29 Sample Evaluations: 5458,
Data Sets: 1282
id23eh1 Sample Evaluations: 8944,
Data Sets: 1824
id23eh2 Sample Evaluations: 9448,
Data Sets: 1102
Total Sample Evaluations: 40235,
Total Data Sets: 6942
ISPyB Data Collection 2008 Total Sample Evaluation: 112616
Total Data Sets: 17514
ISPyB Search in this section only
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